Animal Models

Well characterized and relevant animal models of disease are critical for successful development of antimicrobial drugs and vaccines.  IBT Bioservices has established 15+ highly relevant mouse models of infection up to BSL-2 containment level in-house, and provides BSL-3 and BSL-4 models through partners.  IBT staff have decades of combined experience with animal models of viral and bacterial infections in BSL-2, BSL-3, and BSL-4 settings.

Immunogenicity, pharmacokinetics and toxicity testing are also key studies for drug and vaccine development.  IBT Bioservices can collect samples and perform a wide range of tests such as induction of cytokines/biomarkers, immune responses, drug bioavailability and half-life, gross toxicity, etc.

We regularly develop new animal models, assays and readouts, often per client request.  If you don't see what you need, or have any other questions, please contact us.

Virus Infection Models
Virus Family Genus Species Strain Model Details

 

Togaviridae

 

Alphavirus

Chikungunya


Venezuelan
Equine Encephalitis

181/25

 

TC-83

 

Flaviviridae Flavivirus

Dengue 2

 

Zika

D2Y98P

 

FS 13025

 

 

 

Orthomyxoviridae

 

 

Influenza A

 

 

H1N1

A/Puerto Rico/8/34
A/Texas/36/91
A/California/07/09
A/Perth/261/2009
(Tamiflu-resistant)

 

 

Orthomyxoviridae Influenza A H3N2 A/Hong Kong/1/68
A/Victoria/75
 
Orthomyxoviridae Influenza B   B/40/Lee  
Poxviridae Orthopoxvirus Vaccinia NYCBH  
Paramyxoviridae Pneumovirus Respiratory Syncytial Virus A2

 

Filoviridae

Ebolavirus

 

Marburgvirus

Ebola
Sudan
Marburg
Ebola-Zaire
Boniface
RAVN
 
Coronaviridae Betacoronavirus MERS-CoV Jordan  

 

Bacterial Infection Models
Pathogen Strain Disease Models Model Details
E. coli Enterotoxigenic - H10407 ETEC Intestinal Colonization
Staphylococcus aureus Methicillin Resistant (MRSA-USA300)
Methicillin Sensitive (MSSA)

Pneumonia


Sepsis

 

Streptococcus pneumoniae   Pneumonia

 

 

Bacterial toxins

Staphylococcal Toxic Shock Syndrome Toxin

 

Streptococcal exotoxin

Staphylococcal
Toxic Shock

 

Streptococcal Toxic Shock

 

 

 

Animal Species and Readouts
Animal Species Mouse strains: AG129, BALB/c, C57BL/6, ICR, others
Cotton rat: S. hispidus
Readouts Temperature monitoring via microchip; Microbial burden in blood and organs; Cytokines; Biomarkers