IBT Bioservices' Dengue Virus AG129 mouse model using the D2Y98P dengue clinical isolate is an attractive platform for assessing the efficacy of dengue (DENV) drug and vaccine candidates. This is a lethal model which uses a unique non-mouse-adapted strain of DENV serotype 2 (D2Y98P), isolated from a DENV-infected patient in Singapore, which is highly infectious in AG129 mice. The model is based on the publication of Tan et al. 2010. The model provides consistent clinical manifestations of disease that are similar to human cases.
Other animal models have also been used to study DENV. Non-human primates frequently do not exhibit clinical symptoms of the disease, limiting NHP models usefulness in product development. Other mouse models of DENV exist but face challenges since most DENV laboratory strains and clinical isolates do not replicate efficiently in mice. Mouse-adapted DENV strains can display a higher infectivity but can lead to irrelevant clinical manifestations such as paralysis. Mice deficient in interferon (IFN) alpha/beta and gamma receptors (AG129 mice) have been shown to allow effective replication of DENV, but with great variability in susceptibility to the virus. IBT Bioservices' DENV mouse model overcomes the challenges associated with these previous DENV models,