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Animal Models

Validated and high-quality animal models are critical for successful development of drug and vaccine candidates. IBT Bioservices has established 15+ highly relevant mouse models for infections up to Biosafety Level 2 (BSL- 2) containment in-house and BSL-3 and BSL-4 models through partners. Our staff has decades of combined experience working with viral and bacterial infections in BSL-2, BSL-3, and BSL-4 settings.

In addition to standard models, we offer custom models optimized to address client specific needs to test candidates against specific subtype/strain of pathogen. The suite of in vitro analysis we offer includes cytokine and biomarker induction, immune responses, drug bioavailability and half-life, gross toxicity, microbial burden or viral load in tissue and serum, and more.

We regularly develop new animal models, assays and readouts, often per client request.  If you don’t see what you need, or have any other questions, please contact us.

MODELS FOR VIRUS INFECTION
Virus Family Genus Species Strain Model Details

 

Togaviridae

 

Alphavirus

Chikungunya


Venezuelan
Equine Encephalitis

181/25

 

TC-83

 

 

Flaviviridae

 

Flavivirus

Dengue 2

Zika

D2Y98P

FSS 13025
MR766
PRVABC59

 

 

Orthomyxoviridae

 

Influenza A

 

H1N1 

A/Puerto Rico/8/34
A/Texas/36/91
A/California/07/09
A/Perth/261/2009
(Tamiflu-resistant)

 

 

 

Orthomyxoviridae

 

Influenza A

 

H3N2
 

A/Hong Kong/1/68,
A/Victoria/75

 
Orthomyxoviridae
Influenza B
 
B/40/Lee
 
Paramyxoviridae Pneumovirus
Respiratory Syncytial Virus
A2

 

Filoviridae

Ebolavirus

 

Marburgvirus

Ebola


Sudan
Marburg

Ebola-Zaire


Boniface
RAVN

 

 

MODELS FOR BACTERIAL INFECTION
Pathogen Strain Disease Models Model Details
Escherichia coli Enterotoxigenic - H10407 ETEC Intestinal Colonization
Staphylococcus aureus Methicillin Resistant (MRSA-USA300)
Methicillin Sensitive (MSSA)

Pneumonia
Sepsis

 

Streptococcus pneumoniae DCC 1335, DCC 1420 6b2092 and More Pneumonia

 

 

Bacterial toxins

Staphylococcal Toxic Shock Syndrome Toxin

 

Streptococcal exotoxin

Staphylococcal
Toxic Shock

 

Streptococcal Toxic Shock

 

 

Other Animal Models:

  • Cotton rat (Sigmodon hispidus)
  • Hamster (Golden Syrian)
  • Guinea Pigs (Dunkin Hartley)

Endpoints Available:

  • Survival
  • Health score
  • Weight
  • Temperature (via microchip)
  • Viral load in organs
  • Immunohistochemistry
  • Clinical chemistry
  • Tissue pathology
  • Vascular leakage using Evans Blue dye
  • Cytokine, biomarker and HAI readouts
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Fig. 1 Survival after challenge with INFV H1N1 A/Pert/261/2009 (Tamiflu-resistant strain). Inoculum 1xLD90=1.0E+05 PFU/mouse
Survival after challenge with INFV H1N1 A/Pert/261/2009 (Tamiflu-resistant strain) 1.0E+05 PFU/mouse
Survival and weight change in BALB/c mice challenged with INFV A/ Texas/36/91 (H1N1) and treated with antiviral Osletamivir Phosphate (Tamiflu)
Lung viral load and Survival (30 % weight loss cut-off) in BALB/c mice challenged with INFV H3N2 A/HK/1/68.

Alpha (UK) – B. 1.1.7 / 501Y.V1

amino acid mutations: del69–70 HV, del144 Y, N501Y, A570D, D614G, P681H, T761I, S982A, D1118H

Beta (South Africa) – B.1.351

amino acid mutations: K417N, E484K, N501Y, D614G, A701V

Gamma (Brazil) – P.1

amino acid mutations: L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y, T1027I

Epsilon (Ca, USA) B.1.427

amino acid mutations: L452R, D614G

SARS-CoV-2 Parental Strain Wild Type (Wuhan)
SARS-CoV-2 D614G Variant

amino acid mutations: D614G

Epsilon (Ca, USA) B.1.429

amino acid mutations: S13I, W152C, L452R, D614G

SARS-CoV-2 Delta Variant

amino acid mutations: L452R, E484Q