Validated and high-quality animal models are critical for successful development of drug and vaccine candidates. IBT Bioservices has established 15+ highly relevant mouse models for infections up to Biosafety Level 2 (BSL- 2) containment in-house and BSL-3 and BSL-4 models through partners. Our staff has decades of combined experience working with viral and bacterial infections in BSL-2, BSL-3, and BSL-4 settings.
In addition to standard models, we offer custom models optimized to address client specific needs to test candidates against specific subtype/strain of pathogen. The suite of in vitro analysis we offer includes cytokine and biomarker induction, immune responses, drug bioavailability and half-life, gross toxicity, microbial burden or viral load in tissue and serum, and more.
We regularly develop new animal models, assays and readouts, often per client request. If you don’t see what you need, or have any other questions, let us know how we can assist you.
MODELS FOR VIRUS INFECTION
MODELS FOR BACTERIAL INFECTION
Other Animal Models:
- Cotton rat (Sigmodon hispidus)
- Hamster (Golden Syrian)
- Guinea Pigs (Dunkin Hartley)
- Health score
- Temperature (via microchip)
- Viral load in organs
- Clinical chemistry
- Tissue pathology
- Vascular leakage using Evans Blue dye
- Cytokine, biomarker and HAI readouts