Enterotoxigenic E. Coli Model

For the ETEC Intestinal colonization model, normal flora is eliminated with streptomy- cin and cimetidine is used for stomach deacidification. Mice are then inoculated with ETEC H10407 by gastric gavage and colonization is examined at different time points post chal- lenge by measurement of CFUs in the intestine. Bacterial shedding as well as antibody re- sponse can be measured in stool samples. Lethality endpoint can be determined using high dose challenge.

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Fig. 1 Survival after challenge with INFV H1N1 A/Pert/261/2009 (Tamiflu-resistant strain). Inoculum 1xLD90=1.0E+05 PFU/mouse
Survival after challenge with INFV H1N1 A/Pert/261/2009 (Tamiflu-resistant strain) 1.0E+05 PFU/mouse
Survival and weight change in BALB/c mice challenged with INFV A/ Texas/36/91 (H1N1) and treated with antiviral Osletamivir Phosphate (Tamiflu)
Lung viral load and Survival (30 % weight loss cut-off) in BALB/c mice challenged with INFV H3N2 A/HK/1/68.