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Influenza Infection Models

Preclinical testing of influenza in animal models provides valuable information on virus-host interactions associated with morbidity and mortality. IBT Bioservices has validated infection models for a variety strains that represent disease progression in humans. These challenge models can be used to evaluate  antiviral drugs to immunomodulators designed to counter the pathology of cytokine storm.

Mouse Influenza Models

The mouse offers a convenient and efficient model for lead identification and preclinical analysis of safety and efficacy. The highly characterized murine system offers a reliable model for for evaluating various immunological parameters to address vaccine design and candidate evaluation. While wild mice are highly resistant, inbred laboratory mouse strains such as BALB/c and C57BL/6 mice are susuptible to a variety of influenza viruses. Some strains can cause disease in mice without adaptation but for seasonal H1N1 and H3N2 strains adaptation is required. Changes in body weight, health score and mortality are used to evaluate efficacy of treatments and vaccines against specific strains.

Study Endpoints

    • Health score
    • Weight loss
    • Survival
    • Viral load in organs
    • Cytokines and biomarker and HAI readouts

Validation Data:

    • Survival after challenge with antiviral-resistant H1N1
    • Survival and weight loss after challenge with H1N1
    • Reduction of viral load in lungs and mortality after challenge with H3N2

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