Influenza Mouse Model

Influenza viruses (INFV) are segmented RNA viruses that cause seasonal influenza epidemics and pandemics. Influenza A can infect and be transmitted between birds and some mammals (e.g. pigs and humans). Influenza B only infects humans and seals. Influenza infection poses a severe threat to public health and the agricultural economy. This virus mutates quickly by both antigenic drift and reassortment requiring the development and reformulation of new vaccines each year. Viruses resistant to almost all known drugs have been identified, making drug development a critical pursuit. Concerns about INFV infection are further heightened by the potential for transmission of highly pathogenic avian influenza (HPAI) strains to humans.

IBT Bioservices has developed several mouse models of Influenza infection wherein mice are inoculated intranasally with an LD90 dose of virus.

Influenza Mouse Models

Influenza drug resistance

It is often of interest to test candidate therapies against influenza strains resistant to the standard of care, Tamiflu. IBT Bioservices offers a mouse model using INFV A/Perth/261/2009, which has the naturally occurring H275Y Tamiflu resistance mutation.

IBT Bioservices continues to conduct critical work as an essential business under the State of Maryland’s COVID-19 response directive. We have implemented a risk management plan and are continually monitoring the situation to ensure continuation of research according to public health services recommended best-practices for keeping our employees and the community safe. 

The IBT Bioservices team will continue to deliver high quality products and services for every project. If you have any questions contact us at