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Respiratory Syncytial Virus Cotton Rat Model

RSV infection is responsible for a significant number of respiratory diseases in infants and morbidity in elderly populations. The cotton rat (S. hispidus) is susceptible to non-adapted human RSV. Animals are infected by intranasal inoculation with RSV-A2. This non-lethal model has been used to successfully test RSV vaccine and therapeutic candidates leading to IND and clinical development.

Model kinetics indicate peak viral burden at day 4 or 5 post challenge followed by recovery through day 7. The best indicator of efficacy is viral load at the peak of infection and lung viremia is an indicator of morbidity.

RSVC Rat Model