Staph Aureus Pneumonia Model

In this model intranasal inoculated with the strain of interest. Health checks are performed four times a day within the first 72 hours of infection and once per day until termination of the study. Weight is recorded once daily during the course of disease. Lower, non-lethal inoculum challenge can be performed for CFU determination over extended periods of time. Meta-analysis of results for studies comparing experimental vaccine versus control groups in this model indicate improved survival among vaccinated mice.

Staph Aureus

Fig. 1 Survival after challenge with INFV H1N1 A/Pert/261/2009 (Tamiflu-resistant strain). Inoculum 1xLD90=1.0E+05 PFU/mouse
Survival after challenge with INFV H1N1 A/Pert/261/2009 (Tamiflu-resistant strain) 1.0E+05 PFU/mouse
Survival and weight change in BALB/c mice challenged with INFV A/ Texas/36/91 (H1N1) and treated with antiviral Osletamivir Phosphate (Tamiflu)
Lung viral load and Survival (30 % weight loss cut-off) in BALB/c mice challenged with INFV H3N2 A/HK/1/68.