S Pneumoniae Pneumonia Model

In this model, mice are challenged intranasally with S. pneumoniae. Mice are observed for 5-15 days post infection and survival percentage and health scores are recorded. In vitro assay readouts are available when sublethal doses is used. In vitro assay readouts available include CFUs in blood, lung, spleen or other organs.

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Fig. 1 Survival after challenge with INFV H1N1 A/Pert/261/2009 (Tamiflu-resistant strain). Inoculum 1xLD90=1.0E+05 PFU/mouse
Survival after challenge with INFV H1N1 A/Pert/261/2009 (Tamiflu-resistant strain) 1.0E+05 PFU/mouse
Survival and weight change in BALB/c mice challenged with INFV A/ Texas/36/91 (H1N1) and treated with antiviral Osletamivir Phosphate (Tamiflu)
Lung viral load and Survival (30 % weight loss cut-off) in BALB/c mice challenged with INFV H3N2 A/HK/1/68.