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Toxic Shock Model

IBT Bioservices has established toxic shock models in BALB/c and C57/BL6 for staphylococcal enterotoxins A, B, C, and toxic shock syndrome toxin 1 (TSST-1).  The model utilizes Lipopolysaccharide (LPS) as a potentiating agent as described previously by Stiles et al.  Purfied toxins are administered intraperitoneally followed by an injection of LPS at 4 hours post challenge.  Mice typically succumb to challenge within 24-72 hours.  In addition to morbidity and mortality, cytokine response can be measured at various time points post challenge using a multiplex cytokine assay. For vaccine studies we offer in vitro toxin neutralization evaluation of sera (using human PBMCs).