Toxic Shock Model

IBT Bioservices has established toxic shock models in BALB/c and C57/BL6 for staphylococcal enterotoxins A, B, C, and toxic shock syndrome toxin 1 (TSST-1).  The model utilizes Lipopolysaccharide (LPS) as a potentiating agent as described previously by Stiles et al.  Purfied toxins are administered intraperitoneally followed by an injection of LPS at 4 hours post challenge.  Mice typically succumb to challenge within 24-72 hours.  In addition to morbidity and mortality, cytokine response can be measured at various time points post challenge using a multiplex MSD assay.  In vitro toxin neutralization assays of sera (using human PBMCs) are also available for vaccine studies.

IBT Bioservices continues to conduct critical work as an essential business under the State of Maryland’s COVID-19 response directive. We have implemented a risk management plan and are continually monitoring the situation to ensure continuation of research according to public health services recommended best-practices for keeping our employees and the community safe. 

The IBT Bioservices team will continue to deliver high quality products and services for every project. If you have any questions contact us at