IBT Bioservices has a mouse model for Venezuelan Equine Encephalitis virus (VEEV) that is based on previously described model (Julander, et al., 2008).

In this model, VEEV strain TC-83 is administered intranasally and causes morbidity and mortality with death occurring between 8 and 11 days post infection. Observed similarities to the BSL-3 strain TrD include high virus titers in the brain, cytokine induction, weight loss, and ruffled fur.