Venezuelan Equine Encephalitis Mouse Model

IBT Bioservices has a mouse model for Venezuelan Equine Encephalitis virus (VEEV) that is based on previously described model (Julander, et al., 2008).

In this model, VEEV strain TC-83 is administered intranasally and causes morbidity and mortality with death occurring between 8 and 11 days post infection. Observed similarities to the BSL-3 strain TrD include high virus titers in the brain, cytokine induction, weight loss, and ruffled fur.

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Fig. 1 Survival after challenge with INFV H1N1 A/Pert/261/2009 (Tamiflu-resistant strain). Inoculum 1xLD90=1.0E+05 PFU/mouse
Survival after challenge with INFV H1N1 A/Pert/261/2009 (Tamiflu-resistant strain) 1.0E+05 PFU/mouse
Survival and weight change in BALB/c mice challenged with INFV A/ Texas/36/91 (H1N1) and treated with antiviral Osletamivir Phosphate (Tamiflu)
Lung viral load and Survival (30 % weight loss cut-off) in BALB/c mice challenged with INFV H3N2 A/HK/1/68.