Cornnavirus Variants List

The heavily glycosylated spike (S) protein on its surface give Coronavirus a crown-like appearance. These surface proteins recognize the ACE2 receptors displayed on host cells and facilitate viral entry. As a key determinant of host and cell tropism, antigenicity and immunogenicity, interspecies transmission and pathogenesis¹ the spike protein is an attractive target for antiviral inhibitors and vaccines ^2,3,4. Changes to the amino acid of the spike protein lead to the emergence of new coronavirus variants and will continue to do so.

Amino acid changes that occur during the virus life cycle have can increase transmissibility or virulence of the virus. The table below lists the variants on the  World Health Organization  (WHO) and the CDC watchlist.  The ongoing evolution of SARS-CoV-2 will require continuous research and development to create a therapeutic pipeline to effectively protect against COVID-19. At IBT BioServices we offer a neutralization assay for evaluating antiviral efficacy using recombinant viruses pseudotyped to express the Spike from SARS-CoV2 variants of concern listed below.