Herpes In Vitro

Herpes simplex virus 1 (HSV-1) is a ubiquitous and contagious virus that mainly causes cold sores and also has been found in genital infections. Herpes viruses are neurotropic and can enter a latent stage, escaping the immune system.

A majority of the US population is assumed to be latently infected with herpes viruses. Reactivation can occur sporadically resulting in efficient trasmission to new hosts. There are only a few antivirals to treat the symptoms and reduce transmission rates.

  • Vero cells infected and CPE detected using a standard crystal violet staining

  • HSV-1 CPE by crystal violet staining. Control 1 is virus only and control 2 is cells only
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Fig. 1 Survival after challenge with INFV H1N1 A/Pert/261/2009 (Tamiflu-resistant strain). Inoculum 1xLD90=1.0E+05 PFU/mouse
Survival after challenge with INFV H1N1 A/Pert/261/2009 (Tamiflu-resistant strain) 1.0E+05 PFU/mouse
Survival and weight change in BALB/c mice challenged with INFV A/ Texas/36/91 (H1N1) and treated with antiviral Osletamivir Phosphate (Tamiflu)
Lung viral load and Survival (30 % weight loss cut-off) in BALB/c mice challenged with INFV H3N2 A/HK/1/68.