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Functional Assays

See table below for our current offerings.
Assay Type Antigen Model Details
Hemagglutinin Inhibition Assay H1N1, H3N2, H5N1, H7N9, H10N8
Hemolytic Toxin Neutralization Assay Alpha hemolysin
Non-canonical leukocidin pairs
Leukocidin Toxin Neutralization Assay PVL Luk S/Luk F
Luk ED
Hlg AB
Hlg CB
Superantigen Toxin Neutralization Assay Staphylococcal Enterotoxin A
Staphylococcal Enterotoxin B
Staphylococcal Enterotoxin C
TSST-1
Filovirus GP VSV-pseudotyped Assay Ebola
Sudan
Marburg
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Fig. 1 Survival after challenge with INFV H1N1 A/Pert/261/2009 (Tamiflu-resistant strain). Inoculum 1xLD90=1.0E+05 PFU/mouse
Survival after challenge with INFV H1N1 A/Pert/261/2009 (Tamiflu-resistant strain) 1.0E+05 PFU/mouse
Survival and weight change in BALB/c mice challenged with INFV A/ Texas/36/91 (H1N1) and treated with antiviral Osletamivir Phosphate (Tamiflu)
Lung viral load and Survival (30 % weight loss cut-off) in BALB/c mice challenged with INFV H3N2 A/HK/1/68.

Alpha (UK) – B. 1.1.7 / 501Y.V1

amino acid mutations: del69–70 HV, del144 Y, N501Y, A570D, D614G, P681H, T761I, S982A, D1118H

Beta (South Africa) – B.1.351

amino acid mutations: K417N, E484K, N501Y, D614G, A701V

Gamma (Brazil) – P.1

amino acid mutations: L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y, T1027I

Epsilon (Ca, USA) B.1.427

amino acid mutations: L452R, D614G

SARS-CoV-2 Parental Strain Wild Type (Wuhan)
SARS-CoV-2 D614G Variant

amino acid mutations: D614G

Epsilon (Ca, USA) B.1.429

amino acid mutations: S13I, W152C, L452R, D614G

SARS-CoV-2 Delta Variant

amino acid mutations: L452R, E484Q