Assay Details

This assay tests the neutralization capacity of samples against S. aureus bi-component toxins (leukocidins and gamma-hemolysins) in a neutrophil-like induced HL-60 cell line. Leukocidins act synergistically in pairs to induce damage of monocytes, macrophages and neutrophils. Gamma-lysins also act synergistically but affect leukocytes as well as red blood cells.

We can test the neutralization ability of serum samples against the different toxin pairs Panton-Valentine leukocidin (PVL or LukSF), leukocidin ED (LukED), gamma-hemolysin HlgCB and gamma-hemolysin AB (HlgAB).

IBT Bioservices continues to conduct critical work as an essential business under the State of Maryland’s COVID-19 response directive. We have implemented a risk management plan and are continually monitoring the situation to ensure continuation of research according to public health services recommended best-practices for keeping our employees and the community safe. 

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