Assay Details

Staphylococcal superantigens (sAgs)  bind to human class II major histocompatibility complex (MHC) on antigen-presenting cells and certain subsets of T cell receptor on T lymphocytes. This cross-linking results in massive stimulation of lymphocytes triggering the release of multiple cytokines.

Neutralization of toxin can be measured in vitro by monitoring the reduction in sAg induced interferon-gamma production. These toxin neutralization assays have been established for Staphylococcal Enterotoxin A, Staphylococcal Enterotoxin B, Staphylococcal Enterotoxin C and TSST-1.

IBT Bioservices continues to conduct critical work as an essential business under the State of Maryland’s COVID-19 response directive. We have implemented a risk management plan and are continually monitoring the situation to ensure continuation of research according to public health services recommended best-practices for keeping our employees and the community safe. 

The IBT Bioservices team will continue to deliver high quality products and services for every project. If you have any questions contact us at Services@IBTBioservices.com