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Prophylaxis and immunotherapy of S. aureus/MRSA disease

Staphylococcus aureus (SA) is a Gram-positive bacterium that colonizes approximately one third of the human population1.  It causes a wide range of diseases from skin and soft tissue infections (SSTI) to life-threatening systemic disease such as bacteremia and pneumonia with high mortality rates2,3.  Currently, methicillin-resistant S. aureus (MRSA) is killing as many people…

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Virus-like Particles: Tools for your infectious disease research

Virus-like particles (VLPs) are non-infectious nanoparticles that assemble from recombinantly expressed viral proteins but lack the viral genome required for replication and infection. Because they are non-infectious VLPs do not require the same level of biosafety containment as competent native viruses but retain the self-assembling and antigen presenting capabilities that…

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