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Integrated BioTherapeutics, (IBT) Bioservices, located in Rockville, MD, offers a highly stimulating scientific environment. We believe in teamwork and integration of talent from many disciplines. Here, you will interact with internationally renowned scientists and get involved in collaborations with leading research laboratories and the biotech industry.

Integrated BioTherapeutics is an equal opportunity employer and provides a positive working environment. 

Eligible applicants should send a cover letter, resume and names and contacts of three references to jobs@IntegratedBiotherapeutics.com

 

Current Open Positions:

Post-doctoral Fellow

Integrated BioTherapeutics, Inc (Rockville, MD) is seeking a highly motivated and highly qualified candidate in a lab‐based position as a Post-doctoral Scientist within a dynamic, research-focused group developing viral vaccines and therapeutics against filovirus, Nipah virus and Staphylococcus aureus. The successful candidate will have the opportunity to perform early discovery, set up platform technology development activities, which advances IBT’s biotherapeutics pipeline toward clinical and commercial development. The candidate will be involved in the development of vaccine platforms, including mammalian recombinant protein expression and viral vectors. Additional skillsets in mammalian cell biology, including cell culture maintenance, clone screening, flow cytometry, and small animal studies are highly desired but not required. The successful candidate will help to design and drive innovative improvements to current platform, practices and infrastructure to ensure successful delivery of the project portfolio under supervision of the Chief Scientific Officer. IBT offers a competitive compensation package including health insurance and 401K plan.

Essential Job Responsibilities:

  • Be a key member of the Virology/Bacteriology team that will support the execution of both technology development and pipeline projects.
  • Demonstrate outstanding communication and presentation skills, a documented ability to troubleshoot technical issues, an ability to plan and carry out experiments independently, and to work with complex instrumentation and software.
  • Effectively document all lab activities in notebooks/elsewhere as required and appropriate, in a timely fashion; author technical reports as needed.
  • Read and understand current literature as needed to support setup, troubleshooting and optimization of experiments.
  • Evaluate data and provide clear reports that can be shared and transferred to and from cross‐functional teams, responsible for clear communication in both written (manuscripts) and oral forms.
  • Adherence to safety protocols and knowledge of basic laboratory procedures to advance projects under rapidly shifting priorities and timelines.
  • Support laboratory activities by monitoring lab equipment and maintaining a clean and safe working environment.
  • Required to be onsite; 40H/week; Timing is flexible.

Qualifications:

  • Requires PhD or PhD with <0-1 years’ post-doctoral experience in cell/molecular biology or vaccinology for infectious diseases.
  • Experience with Mammalian cell culture, handling and aseptic technique is critical.
  • Self-motivated and highly productive technical scientist who applies extensive technical and scientific knowledge as well as practical experience to deliver high quality results
  • Molecular biology experience required for this position:
    • DNA cloning, plasmid construction, DNA preparation and analysis
    • DNA transfection
    • DNA/mRNA transfection
    • Immunoprecipitation
  • Strong analytical skills and oral and written communications skills are required.

IBT is committed to publishing its finding in high quality scientific journals. See list of IBT publications.

Please send your applications to Dr. Shweta Kailasan, Principal Scientist/Hiring Manager for this position. skailasan@integratedbiotherapeutics.com

 

Research Associate

Essential Job Responsibilities:

  • Preparation of bacterial culture media, regents and solutions required for bacterial growth.
  • Prepare bacterial challenge dose for in-vivo efficacy studies.
  • Perform serological assays such as ELISAs and toxins neutralization assays in blood, serum, and plasma samples.
  • Perform mammalian cell cultures and cell-based assays such as cytotoxicity and toxin neutralization assay for different bacterial toxins such as: alpha toxins, Leukotoxins, Superantigens, clostridium toxins, anthrax toxins and superantigen toxins.
  • Plasmid and DNA extraction; PCR, cloning and basic molecular biology techniques.
  • Production and purification of Antibody from CHO cell lines and characterization of antibodies
  • Complete a variety of tasks to ensure smooth overall function of laboratory, including simple equipment maintenance, maintain accurate inventories and proper record keeping.
  • Comply with applicable safety procedures working with infectious microorganisms.
  • Oversee Bacterial lab operations:
    • Enforce lab safety protocol to lab personnel (wearing lab coats, gloves)
    • Make sure Labs are neat and tidy.
    • Maintain -80C and -20C inventories.
  • Review/QC and summarize data for reporting to the supervisor.

Qualifications:

Candidate must possess a Masters in biological science and 3+ years of experience.

  • Prior experience in bacterial culture, bacterial enumeration based on total plate count methods and bacterial growth kinetics
  • Prior experience performing serological assays
  • Prior experience performing protein characterization assays: SDS gel, Western Blot and BCA.
  • Must be able to independently run laboratory assays
  • Operating knowledge of Microsoft Office is required
  • Must have an aptitude for problem-solving and be highly organized

 

Integrated BioTherapeutics is an equal opportunity employer and provides a positive working environment.

Eligible applicants should send a cover letter, resume and names and contacts of three references to jobs@IntegratedBiotherapeutics.com

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Fig. 1 Survival after challenge with INFV H1N1 A/Pert/261/2009 (Tamiflu-resistant strain). Inoculum 1xLD90=1.0E+05 PFU/mouse
Survival after challenge with INFV H1N1 A/Pert/261/2009 (Tamiflu-resistant strain) 1.0E+05 PFU/mouse
Survival and weight change in BALB/c mice challenged with INFV A/ Texas/36/91 (H1N1) and treated with antiviral Osletamivir Phosphate (Tamiflu)
Lung viral load and Survival (30 % weight loss cut-off) in BALB/c mice challenged with INFV H3N2 A/HK/1/68.

Alpha (UK) – B. 1.1.7 / 501Y.V1

amino acid mutations: del69–70 HV, del144 Y, N501Y, A570D, D614G, P681H, T761I, S982A, D1118H

Beta (South Africa) – B.1.351

amino acid mutations: K417N, E484K, N501Y, D614G, A701V

Gamma (Brazil) – P.1

amino acid mutations: L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y, T1027I

Epsilon (Ca, USA) B.1.427

amino acid mutations: L452R, D614G

SARS-CoV-2 Parental Strain Wild Type (Wuhan)
SARS-CoV-2 D614G Variant

amino acid mutations: D614G

Epsilon (Ca, USA) B.1.429

amino acid mutations: S13I, W152C, L452R, D614G

SARS-CoV-2 Delta Variant

amino acid mutations: L452R, E484Q