skip to Main Content

Download the IBT Bioservices Guide to In Vitro Antiviral Testing

IBT Bioservices is a provider of research support for the discovery and development of vaccines and therapeutics. We offer a suite of in vitrtests and animal models to support proof-of-concept, product down-selection and to evaluate candidate compound efficacy.

In this document we share with you the molecular and cell-based in vitro antiviral assays IBT Bioservices has to offer to evaluate target and drug activity at each phase of the R&D process.

If you have any questions or would like to share any feedback about this document, we encourage you to be in touch.

    IntegratedBioTherapeutics needs the contact information you provide to us to send you the information you requested. You may unsubscribe from these communications at anytime.

    Back To Top
    Search
    Fig. 1 Survival after challenge with INFV H1N1 A/Pert/261/2009 (Tamiflu-resistant strain). Inoculum 1xLD90=1.0E+05 PFU/mouse
    Survival after challenge with INFV H1N1 A/Pert/261/2009 (Tamiflu-resistant strain) 1.0E+05 PFU/mouse
    Survival and weight change in BALB/c mice challenged with INFV A/ Texas/36/91 (H1N1) and treated with antiviral Osletamivir Phosphate (Tamiflu)
    Lung viral load and Survival (30 % weight loss cut-off) in BALB/c mice challenged with INFV H3N2 A/HK/1/68.

    Alpha (UK) – B. 1.1.7 / 501Y.V1

    amino acid mutations: del69–70 HV, del144 Y, N501Y, A570D, D614G, P681H, T761I, S982A, D1118H

    Beta (South Africa) – B.1.351

    amino acid mutations: K417N, E484K, N501Y, D614G, A701V

    Gamma (Brazil) – P.1

    amino acid mutations: L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y, T1027I

    Epsilon (Ca, USA) B.1.427

    amino acid mutations: L452R, D614G

    SARS-CoV-2 Parental Strain Wild Type (Wuhan)
    SARS-CoV-2 D614G Variant

    amino acid mutations: D614G

    Epsilon (Ca, USA) B.1.429

    amino acid mutations: S13I, W152C, L452R, D614G

    SARS-CoV-2 Delta Variant

    amino acid mutations: L452R, E484Q